Synthesis and SAR Study of T-Type Calcium Channel Blockers. Part II

Authors
Choe, Yun JeongSeo, Han NaJung, Soo YeonRhim, HyewhonKim, JungahnChoo, Dong JoonLee, Jae Yeol
Issue Date
2008-10
Publisher
WILEY-V C H VERLAG GMBH
Citation
ARCHIV DER PHARMAZIE, v.341, no.10, pp.661 - 664
Abstract
3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R-1, a biphenyl group at R-2, and a benzyl amido group at R-3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of Q (KYS05090).
Keywords
DERIVATIVES; ALPHA(1G); RELEASE; MUSCLE; ACID; DERIVATIVES; ALPHA(1G); RELEASE; MUSCLE; ACID; Blockers; 3,4-Dihydroquinazoline; SAR study; T-type calcium channel
ISSN
0365-6233
URI
https://pubs.kist.re.kr/handle/201004/133121
DOI
10.1002/ardp.200800079
Appears in Collections:
KIST Article > 2008
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