Synthesis and SAR Study of T-Type Calcium Channel Blockers. Part II
- Authors
- Choe, Yun Jeong; Seo, Han Na; Jung, Soo Yeon; Rhim, Hyewhon; Kim, Jungahn; Choo, Dong Joon; Lee, Jae Yeol
- Issue Date
- 2008-10
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- ARCHIV DER PHARMAZIE, v.341, no.10, pp.661 - 664
- Abstract
- 3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R-1, a biphenyl group at R-2, and a benzyl amido group at R-3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of Q (KYS05090).
- Keywords
- DERIVATIVES; ALPHA(1G); RELEASE; MUSCLE; ACID; DERIVATIVES; ALPHA(1G); RELEASE; MUSCLE; ACID; Blockers; 3,4-Dihydroquinazoline; SAR study; T-type calcium channel
- ISSN
- 0365-6233
- URI
- https://pubs.kist.re.kr/handle/201004/133121
- DOI
- 10.1002/ardp.200800079
- Appears in Collections:
- KIST Article > 2008
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