DSpace at KISTKIST Article2008

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dc.contributor.authorPark, Hyeong Beom-
dc.contributor.authorJung, Myung Ho-
dc.contributor.authorCho, Jung-Hyuck-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-20T23:01:43Z-
dc.date.available2024-01-20T23:01:43Z-
dc.date.created2021-09-03-
dc.date.issued2008-08-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133295-
dc.description.abstractThe synthesis of a new series of 1 beta-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5-azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectBETA-LACTAM ANTIBIOTICS-
dc.subjectANTIBACTERIAL ACTIVITY-
dc.subjectCARBAPENEM ANTIBIOTICS-
dc.subjectTHIENAMYCIN-
dc.subjectDERIVATIVES-
dc.titleSynthesis and in vitro activity of novel 1 beta-methylcarbapenems having spiro[2,4]heptane moieties. Part II-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.29, no.8, pp.1472 - 1478-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume29-
dc.citation.number8-
dc.citation.startPage1472-
dc.citation.endPage1478-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001524974-
dc.identifier.wosid000259292000010-
dc.identifier.scopusid2-s2.0-50449092605-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBETA-LACTAM ANTIBIOTICS-
dc.subject.keywordPlusANTIBACTERIAL ACTIVITY-
dc.subject.keywordPlusCARBAPENEM ANTIBIOTICS-
dc.subject.keywordPlusTHIENAMYCIN-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordAuthor1 beta-methylcarbapenems-
dc.subject.keywordAuthorantibacterial activity-
dc.subject.keywordAuthorspiro[2,4]heptane-
dc.subject.keywordAuthorsubstituent effects-
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