Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

Abstract

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (11 -8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC50 values ranging from 15 to 30 mu M.