pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Authors
Shim, Woo SunKim, Jong-HoKim, KwangmeyungKim, Yoo-ShinPark, Rang-WoonKim, In-SanKwon, Ick ChanLee, Doo Sung
Issue Date
2007-02-22
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.331, no.1, pp.11 - 18
Abstract
Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX (c) 2006 Elsevier B.V. All rights reserved.
Keywords
CONTROLLED-RELEASE; TRIBLOCK COPOLYMER; DELIVERY-SYSTEM; DRUG-RELEASE; FORMULATION; TAXOL; PLGA; ACID; METASTASES; LIPOSOMES; CONTROLLED-RELEASE; TRIBLOCK COPOLYMER; DELIVERY-SYSTEM; DRUG-RELEASE; FORMULATION; TAXOL; PLGA; ACID; METASTASES; LIPOSOMES; pH/T-sensitive block copolymer hydrogel; injectable hydrogel; paclitaxel; in vivo anti-tumor effect; TUNEL assay
ISSN
0378-5173
URI
https://pubs.kist.re.kr/handle/201004/134638
DOI
10.1016/j.ijpharm.2006.09.027
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KIST Article > 2007
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