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dc.contributor.authorKim, Hwa Sil-
dc.contributor.authorKim, Yoonjee-
dc.contributor.authorDoddareddy, Munikumar Reddy-
dc.contributor.authorSeo, Seon Hee-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorTae, Jinsung-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorCho, Yong Seo-
dc.date.accessioned2024-01-21T01:34:36Z-
dc.date.available2024-01-21T01:34:36Z-
dc.date.created2021-09-05-
dc.date.issued2007-01-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134733-
dc.description.abstractA small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium channel blocking activity with IC50 values of 0.93 and 0.96 mu M, respectively. (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCA2+ CHANNELS-
dc.subjectETHOSUXIMIDE-
dc.subjectPAIN-
dc.titleDesign, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2006.10.042-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.2, pp.476 - 481-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume17-
dc.citation.number2-
dc.citation.startPage476-
dc.citation.endPage481-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000244012200037-
dc.identifier.scopusid2-s2.0-33846104997-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusETHOSUXIMIDE-
dc.subject.keywordPlusPAIN-
dc.subject.keywordAuthorT-type calcium channel blockers-
dc.subject.keywordAuthor1,3-dioxoisoindoline-5-carboxamides-
dc.subject.keywordAuthorpharmacophore model-
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