DSpace at KISTKIST Article2006

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dc.contributor.authorKim, Aihong-
dc.contributor.authorHong, Joon Hee-
dc.contributor.authorOh, Chang Hyun-
dc.date.accessioned2024-01-21T02:01:30Z-
dc.date.available2024-01-21T02:01:30Z-
dc.date.created2021-09-02-
dc.date.issued2006-12-
dc.identifier.issn1525-7770-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134872-
dc.description.abstractA simple synthetic route for novel acyclic phosphonate nucleosides is described. The characteristic cyclopropyl moiety 8 was constructed employing the Simmons-Smith reaction as key step starting from simple acyclic 2-butene-1,4-diol. The condensation of the mesylate 11 with natural nucleosidic bases (A, C, T, U) under nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) and hydrolysis afforded the target nucleosides 16, 17, 18, and 19. In addition, the antiviral evaluations against various viruses were performed.-
dc.languageEnglish-
dc.publisherTAYLOR & FRANCIS INC-
dc.subjectANTIVIRAL ACTIVITY-
dc.subjectMITSUNOBU REACTION-
dc.subjectANALOGS-
dc.subjectDERIVATIVES-
dc.subjectPOTENT-
dc.subjectAGENTS-
dc.subjectVIRUS-
dc.titleSynthesis and anti-HCMV activity of novel cyclopropyl phosphonic acid nucleosides-
dc.typeArticle-
dc.identifier.doi10.1080/15257770600918920-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.25, no.12, pp.1399 - 1406-
dc.citation.titleNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS-
dc.citation.volume25-
dc.citation.number12-
dc.citation.startPage1399-
dc.citation.endPage1406-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000242214700007-
dc.identifier.scopusid2-s2.0-33750485342-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusANTIVIRAL ACTIVITY-
dc.subject.keywordPlusMITSUNOBU REACTION-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusAGENTS-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordAuthorantiviral agent-
dc.subject.keywordAuthorcyclopropyl phosphonic acid nucleosides-
dc.subject.keywordAuthorSimmons-Smith reaction-
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