DSpace at KISTKIST Article2006

Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers

Authors
Lee, Jae Yeol; Park, Seong Jun; Park, Sung Jun; Lee, Min Joo; Rhim, Hyewhon; Seo, Seon Hee; Kim, Ki-Sun
Issue Date
2006-10-01
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.16, no.19, pp.5014 - 5017
Abstract
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords
CA2+ ENTRY; PROLIFERATION; CYCLE; CA2+ ENTRY; PROLIFERATION; CYCLE; cancer cell; growth inhibition; T-type calcium channel blockers; cisplatin
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/135039
DOI
10.1016/j.bmcl.2006.07.046
Appears in Collections:
KIST Article > 2006
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Full Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE