Synthesis and in vitro activity of a series 1 beta-methylcarbapenem derivatives

Abstract

The synthesis of a new series of 1 beta-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIb) having hydroxypyrrolidine moiety showed the most potent antibacterial activity. (c) 2006 Elsevier Masson SAS. All rights reserved.