Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(alpha,beta-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem derivatives. Part II

Authors
Kim, Jin-WoongPark, Hyeong BeomChung, Bong YoungLee, Jong BaekCho, Jung-HyuckOh, Chang-Hyun
Issue Date
2006-08-20
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.27, no.8, pp.1164 - 1170
Abstract
The synthesis of a new series of 1 beta-methylcarbapenems having 5-(alpha,beta-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having alpha-hydroxy-beta-piperazinylethyl substituted moiety showed the most potent activity.
Keywords
BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; THIENAMYCIN; 1-BETA-METHYLCARBAPENEM; BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; THIENAMYCIN; 1-BETA-METHYLCARBAPENEM; 1 beta-methylcarbapenem; antibacterial activity; DHP-I stability
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/135238
Appears in Collections:
KIST Article > 2006
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