Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(alpha,beta-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem derivatives. Part II
- Authors
- Kim, Jin-Woong; Park, Hyeong Beom; Chung, Bong Young; Lee, Jong Baek; Cho, Jung-Hyuck; Oh, Chang-Hyun
- Issue Date
- 2006-08-20
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.27, no.8, pp.1164 - 1170
- Abstract
- The synthesis of a new series of 1 beta-methylcarbapenems having 5-(alpha,beta-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having alpha-hydroxy-beta-piperazinylethyl substituted moiety showed the most potent activity.
- Keywords
- BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; THIENAMYCIN; 1-BETA-METHYLCARBAPENEM; BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; THIENAMYCIN; 1-BETA-METHYLCARBAPENEM; 1 beta-methylcarbapenem; antibacterial activity; DHP-I stability
- ISSN
- 0253-2964
- URI
- https://pubs.kist.re.kr/handle/201004/135238
- Appears in Collections:
- KIST Article > 2006
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