Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(1,2-disubstituted ethyl)-pyrrolidin-3-ylthio]carbapenem derivatives. Part III

Authors
Cho, Jung-HyuckAhn, Soo-HyunJeon, HeecholKim, So YoungOh, Chang-Hyun
Issue Date
2006-05-20
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.27, no.5, pp.705 - 712
Abstract
The synthesis of a new series of 1 beta-methylcarbapenems having 5-(1,2-disubstituted ethyl)pyrrolidine moiety are described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Among them, compound (IIIc) having 1-methoxyimino-2-hydroxyethyl moiety showed the most potent antibacterial activity.
Keywords
BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; THIENAMYCIN; 1-BETA-METHYLCARBAPENEM; BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; THIENAMYCIN; 1-BETA-METHYLCARBAPENEM; 1 beta-methylcarbapenem; antibacterial activity; substituent effect
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/135504
Appears in Collections:
KIST Article > 2006
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE