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Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives

Authors: Nam, G; Kang, TW; Shin, JH; Choi, KI

Issue Date: 2006-02-01

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.16, no.3, pp.569 - 572

Abstract: The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin. (c) 2005 Elsevier Ltd. All rights reserved.

Keywords: ANTIBACTERIAL ACTIVITY; CHEMICAL MODIFICATION; O-METHYLATION; CLARITHROMYCIN; ROXITHROMYCIN; OXIME; ACID; ANTIBACTERIAL ACTIVITY; CHEMICAL MODIFICATION; O-METHYLATION; CLARITHROMYCIN; ROXITHROMYCIN; OXIME; ACID; anti-Helicobacter pylori; erythromycin; oxime ether; MIC; acid stability

ISSN: 0960-894X

URI: https://pubs.kist.re.kr/handle/201004/135757

DOI: 10.1016/j.bmcl.2005.10.045

Appears in Collections:: KIST Article > 2006

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