Sol-gel transition behavior of biodegradable three-arm and four-arm star-shaped PLGA-PEG block copolymer aqueous solution

Authors
Lee, SJHan, BRPark, SYHan, DKKim, SC
Issue Date
2006-01-15
Publisher
WILEY
Citation
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, v.44, no.2, pp.888 - 899
Abstract
Two types of temperature-sensitive biodegradable three-arm and four-arm star-shaped poly(DL-lactic acid-co-glycolic acid-b-ethylene glycol) (3-arm and 4-arm PLGA-PEG) were successfully synthesized via the coupling reaction of 3-arm and 4-arm PLGA and alpha-monocarboxyl-omega-monomethoxypoly(ethylene glycol) (CMPEG), In dilute aqueous solutions, star PLGA-PEGs showed the temperature- and concentration-dependent formation and aggregation of micelles over specific concentration and specific temperature. With increasing the molecular weight and the relative hydrophobicity of hydrophobic PLGA block, critical micelle temperature (CMT) decreased, Aqueous solution of 4-arm PLGA-PEG started to form micelles at lower, temperature and showed sharper temperature-dependent growth in micelle size. These results are due to the enhanced hydrophobicity of PLGA block. On the other hand, at high concentration, two types of 3-arm and 4-arm PLGA-PEG showed sol-gel-sol transition behavior as the temperature was increased. The 3-arm and 4-arm PLGA-PEG Showed sol-gel transition at higher polymer concentrations (above 24 wt %) than the PEG-PLGA-PEG triblock copolymer. As the molecular weight and the relative hydrophobicity of PLGA block increased, the critical gel concentration (CGC) decreased. (c) 2005 Wiley Periodicals, Inc.
Keywords
THERMOREVERSIBLE GELATION; TRIBLOCK COPOLYMER; POLYMERS; PERMEATION; THERMOREVERSIBLE GELATION; TRIBLOCK COPOLYMER; POLYMERS; PERMEATION; star polymers; sol-gel transition; temperature-sensitive hydrogels
ISSN
0887-624X
URI
https://pubs.kist.re.kr/handle/201004/135814
DOI
10.1002/pola.21193
Appears in Collections:
KIST Article > 2006
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE