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dc.contributor.authorOh, CH-
dc.contributor.authorCho, JH-
dc.date.accessioned2024-01-21T03:43:50Z-
dc.date.available2024-01-21T03:43:50Z-
dc.date.created2021-09-02-
dc.date.issued2006-01-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/135870-
dc.description.abstractThe synthesis of a new series of 1 beta-methylcarbapenems having the substituted guanidinocarbonyl pyrrolidine moieties is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. In particular, the compound Ib having piperazinylguanidine moiety showed the most potent antibacterial activity. (c) 2005 Elsevier SAS. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER-
dc.subjectANTIBACTERIAL ACTIVITY-
dc.subjectDERIVATIVES-
dc.subjectCARBAPENEM-
dc.subjectSM-7338-
dc.titleSynthesis and biological evaluation of 1 beta-methylcarbapenems having guanidino moieties-
dc.typeArticle-
dc.identifier.doi10.1016/j.ejmech.2004.12.009-
dc.description.journalClass1-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.41, no.1, pp.50 - 55-
dc.citation.titleEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage50-
dc.citation.endPage55-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000236088800005-
dc.identifier.scopusid2-s2.0-33244497352-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusANTIBACTERIAL ACTIVITY-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusCARBAPENEM-
dc.subject.keywordPlusSM-7338-
dc.subject.keywordAuthor1 beta-methylcarbapenems-
dc.subject.keywordAuthorantibacterial activity-
dc.subject.keywordAuthorsubstituent effects-
dc.subject.keywordAuthorcarbapenems-
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