남강활과 북강활이 혈관운동 및 국소뇌허혈에 미치는 영향

Abstract

Objectives : Gangwhal(羌活) is the root of Angelica koreana Kitagawa and a popular crude drug used to expel wind from the body surface (祛風解表), to remove dampness(祛風濕) and to relieve pain (止痛). The effect was evaluated to the vasomotor responses in rats and focal cerebral ischemic damage by middle cerebral artery occulsion in mice.

Methods : Cerebral ischemia was induced by MCAO and analyzed cerebral blood flow, mean arterial blood pressure, cerebral ischemia area and blood gas by injection water extract of Namganghwal(Ds) and Bukganghwal(Dn).

Results : 1. Vasodilation effect of dried BukGangwhal(Dn) and dried NamGangwhal(Ds) appeared Dn (0.001, 0.01, 0.1, 1, 10g/㎖) by each 1.5±0.84%, 3.5±1.97%, 9.2±2.81%, 19.2±1.58%, and 74.6±1.12% at vein intercept, and vasodilation effect of Ds was the concentration dependence by each 0.5±0.36%, 3.2±1.64%, 4.2±1.71%, 21.4±7.2%, and 76.3±2.03% appeared. 2. Change of brain bloodstream by pre-administrated Ds and Dn in Cerebral ischemia and blood gas induction by MCAO, didn‘t appear.

Conclusion : According to the above results, we found that Dn and Ds could not recognize difference of effect in a comparison experiment about vasomotor and cerebral ischemia.