Styrylquinazolines: A new class of inhibitors on prostaglandin E-2 production in lipopolysaccharide-activated macrophage cells
- Authors
- Park, JH; Min, HY; Kim, SS; Lee, JY; Lee, SK; Lee, YS
- Issue Date
- 2004-01
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- ARCHIV DER PHARMAZIE, v.337, no.1, pp.20 - 24
- Abstract
- 4'-Dihydroxylated styrylquinazolines (2 a-c), 3'-hydroxylated styrylquinazolines 3', (2 h, 2 i), and 3'-acetoxy-styrylquinazolines (2 j, 2 k) exhibited good inhibitory effects of PGE(2) production by COX-2 with a range of IC50 values of 1.19 similar to 3.56 muM. The potencies were comparable or better than that of the representative stilbene resveratrol (IC50 = 3.07 muM). These results indicate that styrylquinazolines can be considered as potential resveratrol analogues in the modulation of prostaglandin production by COX-2.
- Keywords
- RESVERATROL; DERIVATIVES; POTENT; RESVERATROL; DERIVATIVES; POTENT; styrylquinazoline; prostaglandin E-2 (PGE(2)); cyclooxygenase; COX; resveratrol; inflammation; chemoprevention; perkin condensation
- ISSN
- 0365-6233
- URI
- https://pubs.kist.re.kr/handle/201004/137988
- DOI
- 10.1002/ardp.200300791
- Appears in Collections:
- KIST Article > 2004
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