Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted oxadiazolo pyrrolidin-3-yl-thio)carbapenem derivatives

Abstract

Synthesis of a new series of 1beta-methylcarbapenems with a substituted oxadiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the oxadiazole ring investigated. In particular, compounds 13 a and 13 c with ester and carbamoyl substituted oxadiazole moieties showed the most potent antibacterial activity