Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(N-substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio]carbapenem derivatives
- Authors
- Oh, CH; Lee, SC; Cho, JH
- Issue Date
- 2003-07
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.38, no.7-8, pp.751 - 758
- Abstract
- The synthesis of a new series of 1-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, compounds 12b and 12k showed the most potent antibacterial activity. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
- Keywords
- CARBAPENEM; CARBAPENEM; 1 beta-methylcarbapenem; beta-lactam antibiotics
- ISSN
- 0223-5234
- URI
- https://pubs.kist.re.kr/handle/201004/138407
- DOI
- 10.1016/S0223-5234(03)00116-8
- Appears in Collections:
- KIST Article > 2003
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