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dc.contributor.authorKim, Y-
dc.contributor.authorHwang, J-
dc.contributor.authorKim, M-
dc.contributor.authorLee, W-
dc.date.accessioned2024-01-21T09:32:57Z-
dc.date.available2024-01-21T09:32:57Z-
dc.date.created2021-09-01-
dc.date.issued2003-02-
dc.identifier.issn0951-4198-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138897-
dc.description.abstractTripamide is a drug widely used in clinical practice for the treatment of hypertension and edema. This work evaluated a screening method for Tripamide and its urinary metabolites in human urine, using high-performance liquid chromatography diode-array detection (HPLC/DAD). Identification of these metabolites was investigated by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS) after dosing with 15 mg Tripamide. Acid hydrolysis showed that Tripamide is conjugated in the body. Two suspected metabolites were detected by HPLC/DAD. HPLC/ESI-MS/MS analysis suggested that these metabolites were probably hydroxylated together with loss of the -NH2 group and dehydrogenation. These results will be useful in confirmation methods for Tripamide in doping control. Copyright (C) 2003 John Wiley Sons, Ltd.-
dc.languageEnglish-
dc.publisherJOHN WILEY & SONS LTD-
dc.subjectPLASMA-
dc.subjectMETABOLITES-
dc.subjectFUROSEMIDE-
dc.titleDetermination of Tripamide in human urine by high-performance liquid chromatography and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry-
dc.typeArticle-
dc.identifier.doi10.1002/rcm.913-
dc.description.journalClass1-
dc.identifier.bibliographicCitationRAPID COMMUNICATIONS IN MASS SPECTROMETRY, v.17, no.4, pp.301 - 306-
dc.citation.titleRAPID COMMUNICATIONS IN MASS SPECTROMETRY-
dc.citation.volume17-
dc.citation.number4-
dc.citation.startPage301-
dc.citation.endPage306-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000180952800006-
dc.identifier.scopusid2-s2.0-0037278891-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.relation.journalWebOfScienceCategorySpectroscopy-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaSpectroscopy-
dc.type.docTypeArticle-
dc.subject.keywordPlusPLASMA-
dc.subject.keywordPlusMETABOLITES-
dc.subject.keywordPlusFUROSEMIDE-
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