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HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum

Authors
Kim, HJ; Woo, ER; Shin, CG; Hwang, DJ; Park, H; Lee, YS
Issue Date
2001-08
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.24, no.4, pp.286 - 291
Abstract
Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 muM, respectively.
Keywords
IMMUNODEFICIENCY-VIRUS TYPE-1; VERBASCOSIDE; REPLICATION; ESTERS; AIDS; antivirals; HIV-1 integrase inhibitors; Clerodendron trichotomum
ISSN
0253-6269
URI
https://pubs.kist.re.kr/handle/201004/140300
DOI
10.1007/BF02975093
Appears in Collections:
KIST Article > 2001
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