Self-aggregates of deoxycholic acid modified chitosan as a novel carrier of adriamycin

Authors
Lee, KYKim, JHKwon, ICJeong, SY
Issue Date
2000-12
Publisher
SPRINGER-VERLAG
Citation
COLLOID AND POLYMER SCIENCE, v.278, no.12, pp.1216 - 1219
Abstract
A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregated suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).
Keywords
BLOCK-COPOLYMER MICELLES; HYDROGEL NANOPARTICLE; PHYSICAL ENTRAPMENT; DELIVERY; DRUG; STABILIZATION; COMPLEXATION; DERIVATIVES; BLOOD; BLOCK-COPOLYMER MICELLES; HYDROGEL NANOPARTICLE; PHYSICAL ENTRAPMENT; DELIVERY; DRUG; STABILIZATION; COMPLEXATION; DERIVATIVES; BLOOD; chitosan; deoxycholic acid; self-aggregate; nanoparticle; adriamycin
ISSN
0303-402X
URI
https://pubs.kist.re.kr/handle/201004/140906
DOI
10.1007/s003960000389
Appears in Collections:
KIST Article > 2000
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