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dc.contributor.authorNa, HS-
dc.contributor.authorChoi, J-
dc.contributor.authorYu, JH-
dc.contributor.authorShin, KJ-
dc.contributor.authorYoo, KH-
dc.contributor.authorKim, DJ-
dc.contributor.authorPark, SW-
dc.date.accessioned2024-01-21T16:33:13Z-
dc.date.available2024-01-21T16:33:13Z-
dc.date.created2022-01-10-
dc.date.issued1998-11-01-
dc.identifier.issn0385-5414-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/142742-
dc.description.abstractThe synthesis and enzyme assay of 2,8-dihydroxyindolizidines (5) were described. Four diastereomers of these were prepared from trans-4-hydroxy-L-proline (6) which is commercially available amino acid. Among synthetic compounds 5a(1) and 5b(2) showed medium potent inhibition to alpha-amyloglycosidase, while 5a(2) displayed medium activity to alpha-glucosidase.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectALPHA-MANNOSIDASE-
dc.subjectSWAINSONA-CANESCENS-
dc.subjectGLUCOSIDASE-
dc.titleSynthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationHETEROCYCLES, v.48, no.11, pp.2365 - 2378-
dc.citation.titleHETEROCYCLES-
dc.citation.volume48-
dc.citation.number11-
dc.citation.startPage2365-
dc.citation.endPage2378-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000077403000015-
dc.identifier.scopusid2-s2.0-0001652191-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusALPHA-MANNOSIDASE-
dc.subject.keywordPlusSWAINSONA-CANESCENS-
dc.subject.keywordPlusGLUCOSIDASE-
dc.subject.keywordAuthorIndolizidine Alkaloids-
dc.subject.keywordAuthor2,8-Dihydroxyindolizidines-
dc.subject.keywordAuthorGlycosidase Inhibitor-
dc.subject.keywordAuthorFour Diastereomers-
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