Full metadata record

DC Field Value Language
dc.contributor.authorCho, Hee Young-
dc.contributor.authorLee, Ji Eun-
dc.contributor.authorPark, Kyo Hoon-
dc.contributor.authorChoi, Bo Young-
dc.contributor.authorLee, Min Jung-
dc.contributor.authorJeong, Da Eun-
dc.contributor.authorShin, Sue-
dc.date.accessioned2024-06-28T02:00:09Z-
dc.date.available2024-06-28T02:00:09Z-
dc.date.created2024-06-27-
dc.date.issued2024-06-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/150121-
dc.description.abstractThis study aimed to identify plasma proteins that could serve as potential biomarkers for microbial invasion of the amniotic cavity (MIAC) or intra-amniotic inflammation (IAI) in women with preterm labor (PTL). A retrospective cohort comprised singleton pregnant women with PTL (24?34 weeks) who underwent amniocentesis. Pooled plasma samples were analyzed by label-free liquid chromatography-tandem mass spectrometry for proteome profiling in a nested case?control study (concomitant MIAC/IAI cases vs. non-MIAC/IAI controls [n?=?10 per group]). Eight target proteins associated with MIAC/IAI were further verified by immunoassays in a large cohort (n?=?230). Shotgun proteomic analysis revealed 133 differentially expressed proteins (fold change?>?1.5, P?<?0.05) in the plasma of MIAC/IAI cases. Further quantification confirmed that the levels of AFP were higher and those of kallistatin and TGFBI were lower in the plasma of women with MIAC and that the levels of kallistatin and TGFBI were lower in the plasma of women with IAI than in those without these conditions. The area under the curves of plasma AFP, kallistatin, and TGFBI ranged within 0.67?0.81 with respect to each endpoint. In summary, plasma AFP, kallistatin, and TGFBI may represent valuable non-invasive biomarkers for predicting MIAC or IAI in women with PTL.-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.titleIdentification and characterization of plasma proteins associated with intra-amniotic inflammation and/or infection in women with preterm labor-
dc.typeArticle-
dc.identifier.doi10.1038/s41598-024-65616-x-
dc.description.journalClass1-
dc.identifier.bibliographicCitationScientific Reports, v.14, no.1-
dc.citation.titleScientific Reports-
dc.citation.volume14-
dc.citation.number1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid001255006800069-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.type.docTypeArticle-
dc.subject.keywordPlusSERUM ALPHA-FETOPROTEIN-
dc.subject.keywordPlusPROTEOMIC ANALYSIS-
dc.subject.keywordPlusMATERNAL PLASMA-
dc.subject.keywordPlusBIOMARKERS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPREDICTION-
dc.subject.keywordPlusEPIDEMIOLOGY-
dc.subject.keywordPlusPREECLAMPSIA-
dc.subject.keywordPlusKALLISTATIN-
dc.subject.keywordPlusAMNIOTIC-FLUID-
Appears in Collections:
KIST Article > 2024
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE