Common feature hypothesis based virtual screening of 5-HT2C agonists using HipHop and HipHopRefine module of CATALYST
- Common feature hypothesis based virtual screening of 5-HT2C agonists using HipHop and HipHopRefine module of CATALYST
- 배애님; 아시프; 추현아; 조용서
- 5-HT2c; agonist; 비만
- Issue Date
- Assay and Cellular Target
- Four feature 3D pharmacophore was generated using seven highly active 5-HT2C agonists.
Hits from this pharmacophore had moderate activity
HipHopRefine pharmacophore with more discrimination power was generated at second stage.
Virtual screening hits of commercial database using HipHopRefine pharmacophore resulted more active leads.
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- KIST Publication > Conference Paper
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