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dc.contributor.author쩡꿔위-
dc.contributor.authorWang, Xue-Mei-
dc.contributor.author고현석-
dc.contributor.author양현옥-
dc.date.accessioned2015-12-02T15:41:27Z-
dc.date.available2015-12-02T15:41:27Z-
dc.date.issued201007-
dc.identifier.citationVOL 130, NO 1, 13-18-
dc.identifier.issn0378-8741-
dc.identifier.other33461-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/38430-
dc.description.abstractAim of the study: To investigate the neuroprotective effect of aqueous extract of modified Wu-Zi-Yan-Zong granule (MWG), a traditional Chinese herbal medicine, against CoCl2-induced neurotoxicity in PC12 cells. Materials and methods: Cell viability assay, apoptosis rate assay, ROS detection and mitochondrial membrane potential (MMP) assay were performed. In addition, cytochrome c, caspase-3, PARP and MAPKs were also detected by Western blotting. Results: MWG extract increased viability and suppresses early and middle/late stage apoptosis in a dose-dependent manner in CoCl2-induced PC12 cells. Moreover, MWG extract decreased the level of intracellular reactive oxygen species (ROS), increased MMP, regulated Bcl-2 family protein expression (Bcl-2 and Bcl-XL) and inhibited the release of cytochrome c from the mitochondria. In addition, MWG extract attenuated activation of caspase-3 and poly ADP-ribose polymerase (PARP) and inhibited the phosphorylation of ERK, c-Jun NH2-terminal kinase (JNK) and p38 MAPKs. Conclusions: MWG extract exhibited significant neuroprotective effect on PC12 cells, and this effect may be associated with the suppression of ROS generation and inhibition of mitochondria-mediated caspase and MAPK signaling pathways.-
dc.publisherJournal of ethnopharmacology-
dc.subjectNeuroprotection-
dc.subjectModified Wu-Zi-Yan-Zong granule-
dc.subjectTraditional Chinese medicine-
dc.subjectPC12 cells-
dc.subjectCobalt chloride-
dc.titleNeuroprotective effect of modified Wu-Zi-Yan-Zong ganule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells-
dc.typeArticle-
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