Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Title
Hybrid ferritin nanoparticles as activatable probes for tumor imaging
Authors
Xin LinJin XieLei Zhu이슬기Gang NiuYing Ma김광명Xiaoyuan Chen
Keywords
ferritin; fluorescent probes; imaging agents; metalloenzymes; nanoparticles
Issue Date
2011-02
Publisher
Angewandte Chemie international edition
Citation
VOL 50, NO 7, 1569-1572
Abstract
Near-infrared fluorescence (NIRF) imaging is emerging as an important tool in preclinical studies.[1–5] As the technology is being established and implemented worldwide, a wave of effort has been spurred to develop novel imaging probes that can accurately recognize and report diseases, such as cancer.[3, 6] One common drawback of NIRF imaging, however, is its high background and as a consequence of that, low specificity.[7, 8] To address this issue, we and others have developed activatable probes with various approaches. Such probes, constructed by bringing into proximity an energy donor and receptor, are designed to be fluorescently quenched at a quiescent stage but activatable when encountering a specific trigger, which leads to a structural or conformational change and restores fluorescence activities.[ 7–9] This technique allows the signals to be only amplified at diseased areas upon a designated environment change, a feature which can greatly improve the signal-to-background ratio.
URI
https://pubs.kist.re.kr/handle/201004/39554
ISSN
1433-7851
Appears in Collections:
KIST Publication > Article
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