Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium
- Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium
- 이소영; 최정일; 신상원; 임연민; 송종한; 강상수; 남태현; Thomas J. Webster; 김상현; 강동우
- Immunotoxicity; Implant; Macrophage; Titanium; Live cell migration
- Issue Date
- Acta Biomaterialia
- VOL 7, NO 5, 2337-2344
- The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and
orthopedic applications. However, it has been unclear whether implanted surface nanostructures can
inhibit or aggrevate inflammatory responses. Herein, macrophage activation, as evidence of migration,
on transparent flat and nanostructured titanium correlated with pro-inflammatory protein synthesis
and cytokine release. Through the real-time monitoring of initial cytoskeleton variations, this study identified
that macrophage movement was restricted on nanostructured titanium compared to flat titanium
surfaces. Furthermore, nanostructured titanium elicited secretion of fewer pro-inflammatory enzyme
molecules and cytokines, as well as reduced nitric oxide production. All results collectively indicated that
initial macrophage activation can be mitigated by nanoscale surface topography alone, without modification
of surface chemistry or stiffness.
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