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dc.contributor.author한민수-
dc.contributor.author한영휘-
dc.contributor.author송치만-
dc.contributor.author한호규-
dc.date.accessioned2015-12-03T00:50:49Z-
dc.date.available2015-12-03T00:50:49Z-
dc.date.issued201208-
dc.identifier.citationVOL 33, NO 8, 2597-2602-
dc.identifier.issn02532964-
dc.identifier.other37905-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/43132-
dc.description.abstractNovel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.-
dc.publisherBulletin of the Korean Chemical Society-
dc.subjectantidepression-
dc.subjectCNS drug-
dc.subjectpiperazine-
dc.subjectMajor depressive disorder-
dc.subjectAntidepressants-
dc.subjectTriple reuptake inhibitor-
dc.titleThe Design and Synthesis of 1,4-Substituted Piperazine Derivatives as Triple Reuptake Inhibitors-
dc.typeArticle-
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