Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores
- Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores
- Hee-Kyung Na; Mi-Hee Kim; Kihyun Park; Soo-Ryoon Ryoo; 이경은; 전혜성; Ryong Ryoo; Changbong Hyeon; Dal-Hee Min
- cancer therapy; drug delivery; mesoporous materials; nanoparticles; RNA interference
- Issue Date
- VOL 8, NO 11, 1752-1761
- Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug-delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post-transcriptional gene silencing, so-called RNA interference. Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity.
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