Functional mouse brain mapping and its application to sleep study
- Functional mouse brain mapping and its application to sleep study
- 최지현; E. HWANG; B. KIM; S. LEE; S. HAN; Y. KIM; R. STRECKER
- EEG; SLEEP; THALAMOCORTICAL
- Issue Date
- Society for neuroscience
- In 2010, a new methodology called high resolution electroencephalography (HR-EEG) for mouse brain was
introduced in Journal of Neurophysiology (Choi JH, Koch KP, Poppendieck W, Lee M, Shin HS (2010) High
resolution electroencephalography in freely moving mice. J Neurophysiol 104: 1825-1834; Lee M, Kim D, Shin
H-S, Sung H-G, Choi JH (2011) High-density EEG Recordings of the Freely Moving Mice using Polyimidebased
Microelectrode. J Vis Exp: e2562). By combining this new technique with conventional local field
potential recording in thalamus, we revisited the sleep wave including sleep spindle, K-complex, and slowwave
sleep oscillation in the viewpoint of the generation, propagation, and termination of these waves. We
analyze the spatio-temporal patterns of the sleep waves and performed causality study between sleep waves
in cortex and thalamus. We also analyzed the structures of sleep wave under the condition of acute sleep
deprivation as well as chronic sleep deprivation.
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