Full metadata record

DC FieldValueLanguage
dc.contributor.author모하메드엘가말-
dc.contributor.author최홍석-
dc.contributor.author유경호-
dc.contributor.author백대진-
dc.contributor.author오창현-
dc.date.accessioned2015-12-03T01:03:32Z-
dc.date.available2015-12-03T01:03:32Z-
dc.date.issued201309-
dc.identifier.citationVOL 82, NO 3, 336-347-
dc.identifier.issn17470277-
dc.identifier.other40618-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/46295-
dc.description.abstractA series of 3,4-diarylpyrazole-1-carboxamide derivatives was designed and synthesized. A selected group of the target compounds was tested for in vitro antiproliferative activities over a panel of 60 cancer cell lines at the National Cancer Institute (NCI, Bethesda, MD, USA) at a single-dose concentration of 10 lM, and the four most active compounds 9a, 9l, 9n, and 10o were further tested in a five-dose testing mode to determine their IC50 values over the 60 cell lines. In addition, a selected group of target compounds were tested for inhibitory effect over cyclooxygenase isozymes. Compounds 9a, 9l, 9n, and 10o were also tested for MEK and ERK kinase inhibitory activity using Western blot assay. Compound 10o was selective toward melanoma cell line subpanel, and its antiproliferative activity may be attributed to selective cyclooxygenase- 2 inhibition and ERK pathway inhibition.-
dc.publisherChemical biology & drug design-
dc.subjectERK pathway-
dc.subjectcyclooxygenase-2-
dc.subject3,4-diarylpyrazole-1-carboxamide-
dc.subjectanticancer-
dc.subjectpyrazole-
dc.subjectvicinal diaryl heterocycle-
dc.titleAntiproliferative Diarylpyrazole Derivatives as Dual Inhibitors of the ERK Pathway and COX-2-
dc.typeArticle-
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE