Hydrophilic and anti-fouling nanochannel fabrication using poly(ethylene glycol)-mediated bonding
- Hydrophilic and anti-fouling nanochannel fabrication using poly(ethylene glycol)-mediated bonding
- 맹준호; 차병준; 신현준; 이상엽
- nanochannel; hydrophilic; anti-fouling; poly(ethylene glycol); nanoimprint lithography; 나노채널; 친수성; 흡착방지; 폴리에틸렌 글라이콜; 나노임프린트 리소그래피
- Issue Date
- 대한기계학회 2013년도 학술대회
- , 2214-2219
- We present a method to fabricate polymer nanochannel using novel poly(ethylene glycol) (PEG)-mediated bonding method. The proposed method enables rapid prototyping of hydrophilic and anti-fouling nanochannel by nanoimprint lithography (NIL) without using a sophisticated procedures and equipment. PEG chain was employed as an intermediate layer between nanoimprinted polymer substrate and glass cover plate for substrates bonding. In order to form PEG intermediate layer, methoxy PEG (mPEG)-epoxide was covalently coupled with hydroxyl group on the polymer substrate generated by oxygen plasma treatment. Then, both PEG-coated polymer substrate and glass cover plate were exposed to oxygen plasma again. The fabricated rectangular nanochannel consists of three PEG-coated polymer walls and a glass wall. The resultant PEG-coated nanochannel exhibited a long-lived hydrophilic surface and excellent anti-fouling effect for DNA molecules. In addition, nanochannel was completely leak-free to small molecules such as FITC. To evaluate the potential use of PEG-coated nanochannel in DNA analysis, relationship between various nanocomfinements and linear conformations of λ-DNA was investigated.
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