Bioavailability of Ginsenosides from White and Red Ginsengs in the Simulated Digestion Model
- Bioavailability of Ginsenosides from White and Red Ginsengs in the Simulated Digestion Model
- 김은옥; 차광현; 이은하; 김상민; 최상원; 판철호; 엄병헌
- white ginseng; red ginseng; bioavailability; digestive stability; ginsenosides; simulated digestion; white and red ginsengs
- Issue Date
- Journal of agricultural and food chemistry
- VOL 62, NO 41, 10055-10063
- This study aims to investigate the bioavailability of ginsenosides during simulated digestion of white (WG) and red (RG) ginseng powders. Stability, bioaccessibility, and permeability of ginsenosides present in WG and RG were studied in a Caco-2 cell culture model coupled with oral, gastric, and small intestinal simulated digestion. Most ginsenosides in WG and RG were stable (>90%) during the simulated digestion. Bioaccessibilities of total ginsenosides during in vitro digestion of WG and RG were similar at approximately 85%. However, the bioaccessibility of protopanaxatriol type ginsenosides in the early food phase was greater than that of the protopanaxadiol type. The less polar RG ginsenosides were released later following the jejunum phase. Ginsenosides had low permeability (<1 × 10−6 cm/s) through Caco-2 cell monolayers. These findings suggest that the WG and RG ginsenoside compositions affect bioaccessibility during digestion and that ginsenosides are poorly absorbed in humans.
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