Theranostic nanomaterials for image-guided gene therapy
- Theranostic nanomaterials for image-guided gene therapy
- 황승림; 구숙희; 주민경; 김선화; 권익찬
- biomedical; biomaterial; nanoscale
- Issue Date
- MRS bulletin
- VOL 39, NO 1, 44-50
- Theranostics was proposed as a combined process of therapeutics and diagnostics
methodology for increasing treatment effi cacy and safety with simultaneous monitoring of
the response to treatment. In the past two decades, nanotechnology has been the focus
of developing strategies for drug delivery and imaging functions, and it has expanded
to the design of multifunctional nanoparticles and the creation of “nanotheranostics”
(i.e., theranostic nanomedicines). Nanotheranostics also shows potential in gene therapy;
however, nanoparticle-mediated delivery of genes still faces major obstacles related to (1) theuptake by the reticuloendothelial system, (2) the ability to get across the target cell membranes through endocytosis, and (3) the ability to accumulate in organs with permeable vasculature. Here, we review the development and application of nanotheranostics, highlighting their
relevance to gene therapy as well as molecular imaging.
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