Full metadata record

DC FieldValueLanguage
dc.contributor.author권재영-
dc.contributor.authorTaehun Lee-
dc.contributor.authorDongho Lee-
dc.contributor.authorWoongchon Mar-
dc.date.accessioned2021-06-09T04:16:59Z-
dc.date.available2021-06-09T04:16:59Z-
dc.date.issued2015-06-
dc.identifier.citationVOL 63-5467-
dc.identifier.issn0021-8561-
dc.identifier.other47642-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/64908-
dc.description.abstractCudrania tricuspidata fruit extract contains a rich source of prenylated flavonoids with potential antiatherosclerotic, hepatoprotective, and anti-inflammatory properties. However, the effect of C. tricuspidata fruit extracts and its active compounds on the high-affinity IgE receptor (FceRI)-mediated signaling remains unknown. In the present study, the effect of methanol extract from the fruits of C. tricuspidata (MFC) and its active compound, 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (THDPI), on FceRI-mediated signaling in mast cells was investigated. MFC and THDPI suppressed mast cell degranulation and Ca2+ influx. MFC also interfered with IgE-FceRI interaction and decreased FceRI beta mRNA expression in mast cells. Furthermore, MFC and THDPI inhibited the phosphorylation of Syk, LAT, and PLC gamma and F-actin redistribution. These results indicate that MFC and its active compound, THDPI, inhibit mast cell activation through the inhibition of FceRI-mediated Syk activation, suggesting a therapeutic potential for controlling mast cell activation in inflammatory and/or allergic processes.-
dc.publisherJournal of agricultural and food chemistry-
dc.titleEffects of Cudrania tricuspidata Fruit Extract and Its Active Compound, 5,7,3 ',4 '-Tetrahydroxy-6,8-diprenylisoflavone, on the High-Affinity IgE Receptor-Mediated Activation of Syk in Mast Cells-
dc.typeArticle-
dc.relation.page54595467-
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE