Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering
- Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering
- 이현정; Alec S.T.Smith; Hyok Yoo; Eun Hyun Ahn; Justin H. Lee; Guozheng Shao; Ekaterina Nagornyak; Michael A. Laflamme; Charles E. Murry; Deok-Ho Kim
- Issue Date
- Chemical communications
- VOL 53-7415
- A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphenefunctionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constructs displayed structural property enhancement in myofibrils and sarcomeres, and exhibited significant increases in the expression of cell– cell coupling and calcium handling proteins, as well as in action potential duration and peak calcium release.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.