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dc.contributor.author김동진-
dc.contributor.author김윤경-
dc.contributor.author김도희-
dc.contributor.author임성수-
dc.date.accessioned2021-06-09T04:18:42Z-
dc.date.available2021-06-09T04:18:42Z-
dc.date.issued2016-12-
dc.identifier.citationVOL 1523-347-
dc.identifier.issn1064-3745-
dc.identifier.other49582-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/66407-
dc.description.abstractAbnormal tau aggregation is a pathological hallmark of neurodegenerative disease classified as tauopathy. Preventing tau aggregation becomes an important therapeutic strategy to cure tau-mediated neurodegeneration. Here, we describe a method to investigate intracellular tau aggregation by using a recently developed tau aggregation cell-based model named tau-BiFC. High-throughput and high-contents screening method for quantifying intracellular tau aggregation would expedite the discovery of drugs that inhibit tau aggregation.-
dc.publisherMethods in Molecular Biology-
dc.subjectTau protein-
dc.subjectTau aggregation-
dc.subjectTau-BiFC cells-
dc.subjectTau phosphorylation-
dc.subjectForskolin-
dc.subjectCell image analysis-
dc.subjectHigh content imaging system (Operetta™)-
dc.subjectHarmony? software-
dc.titleImage-based analysis of intracellular tau aggregation by using tau-BiFC cell model-
dc.typeOther-
dc.relation.page341347-
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