Bulk Aggregation Based Fluorescence Turn-On Sensors for Selective Detection of Progesterone in Aqueous Solution
- Bulk Aggregation Based Fluorescence Turn-On Sensors for Selective Detection of Progesterone in Aqueous Solution
- 이준석; 디라제무라레; 홍성철; 이민주; 이승미; 박중신
- bulk aggregation; dansyl fluorophore; fluorescence sensor; self-aggregation; progesterone
- Issue Date
- Angewandte Chemie international edition
- VOL 56, NO 46-14647
- Steroids are polycyclic compounds that share tetracyclic ring as core scaffold, and selective detection of a steroid is challenging owing to their structural similarities. The discovery of chemosensors that recognize progesterone by alteration of self-aggregation state is described, and these show significant fluorescence turn-on. A self-aggregated 48-membered dansyl library was screened against a series of metabolites in aqueous buffer and discovered two compounds (PG-
1, PG-2) exhibited exceptional selectivity for progesterone. Following studies of aggregation properties of probes using dynamic light scattering and transmission electron microscopy supports progesterone recognition lead to the generation of bulk aggregates that induce fluorescence enhancement. Though many fluorescence sensing mechanisms have been proposed, a sensing mode based on the bulk aggregate formation of fluorophore has never been reported, and this
may open a new avenue of chemosensor design.
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