Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus
- Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus
- 김정진; 류이치 나카지마; 김영수; 신안나; 정민주; 박아형; 정용철; 조선미; 양승경; 박호성; 조성환; 심인섭; 정재훈; 백세범; 조지 어거스틴; 김대수
- Issue Date
- VOL 95, NO 5-1196
- Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca2+ channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities.
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