In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering
- In situ cross-linkable hyaluronic acid hydrogels using copper free click chemistry for cartilage tissue engineering
- 김광명; 윤홍열; 한상수; 이지영; 조명옥; 심혜은; 정지은; 이동은; 김환욱; 이존환; 허강무; 강선웅
- Issue Date
- Polymer Chemistry
- VOL 9, NO 1-27
- We report a biocompatible and in situ cross-linkable hydrogel derived from hyaluronic acid via a bioorthogonal reaction and confirm the clinical potential of our hydrogel through in vivo cartilage regeneration. Gelation is attributed to copper-free click reactions between an azide and dibenzyl cyclooctyne. HA-PEG4-DBCO was synthesized and cross-linked via 4-arm PEG azide. The effects of the ratio of HA-PEG4-DBCO to 4-arm PEG azide on the gelation time, microstructure, surface morphology, equilibrium swelling, and compressive modulus were examined. The potential of a hydrogel as an injectable scaffold was demonstrated by the encapsulation of chondrocytes within the hydrogel matrix in vitro and in vivo. The results demonstrated that the hydrogel supported cell survival, and the cells regenerated cartilaginous tissue. In addition, these characteristics provide potential opportunities for the use of injectable hydrogels in tissue engineering applications.
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