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dc.contributor.author오승자-
dc.contributor.authorLorraine C. Santy-
dc.date.accessioned2021-06-09T04:19:33Z-
dc.date.available2021-06-09T04:19:33Z-
dc.date.issued2010-05-
dc.identifier.citationVOL 285, NO 19-14616-
dc.identifier.issn0021-9258-
dc.identifier.other50281-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/67155-
dc.description.abstractADP-ribosylation actor 6 (ARF6) regulates the endocytosis and recycling of a variety of proteins and also promotes peripheral actin rearrangements and cell motility. ARF6 is activated by a large number of guanine nucleotide exchange factors, which likely regulate ARF6 at different locations and during different processes. In this study we investigate the roles of the cytohesin ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors during the recycling of integrin beta 1. Intriguingly, we find that knockdown and overexpression of ARNO/cytohesin 2 and GRP1/cytohesin 3 have opposing effects on cell adhesion and spreading on fibronectin and on cell migration. We find that ARNO/cytohesin 2 is required for integrin beta 1 recycling, whereas GRP1/cytohesin 3 is dispensable for this process. This is the first demonstration of unique roles for these proteins.-
dc.publisherThe Journal of biological chemistry-
dc.titleDifferential effects of cytohesins 2 and 3 on beta1 integrin recycling-
dc.typeArticle-
dc.relation.page1461014616-
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