Emerging Roles of TWIK-1 Heterodimerization in the Brain
- Emerging Roles of TWIK-1 Heterodimerization in the Brain
- 황은미; Chang-Hoon Cho; Jae-Yong Park
- TWIK-1; K2P; astrocyte; brain; heterodimerization
- Issue Date
- International journal of molecular sciences
- VOL 19, NO 1, 51
- Two-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK— tandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.
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