Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities

Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities
우덕하전영민이석김재헌이택진김철기서민아최재빈박현서오승자유용상이동규김효석박병호조영호오주영Heehong YangTai Hwan HaSeok Hwan KimHyuk-Jae LeeSeong Chan JunHyun Seok SongTai Hyun Park
Artificial biomaterials; rod; cone; spectral sensitivity; graphene; spectral characteristics
Issue Date
Advanced materials
VOL 30, NO 27-1706764-8
Photosensitive materials contain biologically engineered elements and are constructed using delicate techniques, with special attention devoted to efficiency, stability, and biocompatibility. However, to date, no photosensitive material has been developed to replace damaged visual-systems to detect light and transmit the signal to a neuron in the human body. In the current study, artificial nanovesicle-based photosensitive materials are observed to possess the characteristics of photoreceptors similar to the human eye. The materials exhibit considerably effective spectral characteristics according to each pigment. Four photoreceptors originating from the human eye with colordistinguishability are produced in human embryonic kidney (HEK)-293 cells and partially purified in the form of nanovesicles. Under various wavelengths of visible light, electrochemical measurements are performed to analyze the physiological behavior and kinetics of the photoreceptors, with graphene, performing as an electrode, playing an important role in the lipid bilayer deposition and oxygen reduction processes. Four nanovesicles with different photoreceptors, namely, rhodopsin (Rho), short-, medium-, and longwave sensitive opsin 1 (1SW, 1MW, 1LW), show remarkable color-dependent characteristics, consistent with those of natural human retina. With four different light-emitting diodes for functional verification, the photoreceptors embedded in nanovesicles show remarkably specific color sensitivity. This study demonstrates the potential applications of light-activated platforms in biological optoelectronic industries.
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