Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities
- Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities
- 우덕하; 전영민; 이석; 김재헌; 이택진; 김철기; 서민아; 최재빈; 박현서; 오승자; 유용상; 이동규; 김효석; 박병호; 조영호; 오주영; Heehong Yang; Tai Hwan Ha; Seok Hwan Kim; Hyuk-Jae Lee; Seong Chan Jun; Hyun Seok Song; Tai Hyun Park
- Artificial biomaterials; rod; cone; spectral sensitivity; graphene; spectral characteristics
- Issue Date
- Advanced materials
- VOL 30, NO 27-1706764-8
- Photosensitive materials contain biologically engineered elements and are constructed using delicate techniques, with special attention devoted to efficiency, stability, and biocompatibility. However, to date, no photosensitive material has been developed to replace damaged visual-systems to detect light and transmit the signal to a neuron in the human body. In the current study, artificial nanovesicle-based photosensitive materials are observed to possess the characteristics of photoreceptors similar to the human eye. The materials exhibit considerably effective spectral characteristics according to each pigment. Four photoreceptors originating from the human eye with colordistinguishability are produced in human embryonic kidney (HEK)-293 cells and partially purified in the form of nanovesicles. Under various wavelengths of visible light, electrochemical measurements are performed to analyze the physiological behavior and kinetics of the photoreceptors, with graphene, performing as an electrode, playing an important role in the lipid bilayer deposition and oxygen reduction processes. Four nanovesicles with different photoreceptors, namely, rhodopsin (Rho), short-, medium-, and longwave sensitive opsin 1 (1SW, 1MW, 1LW), show remarkable color-dependent characteristics, consistent with those of natural human retina. With four different light-emitting diodes for functional verification, the photoreceptors embedded in nanovesicles show remarkably specific color sensitivity. This study demonstrates the potential applications of light-activated platforms in biological optoelectronic industries.
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