Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition
- Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition
- 정상훈; Jeong-Hyeon Ko; Dongwoo Nam; Jae-Young Um; Gautam Sethi; Kwang Seok Ahn
- bergamottin; EMT; metastasis; lung cancer
- Issue Date
- VOL 23, NO 7, 1601
- Bergamottin (BGM) is a naturally occurring furanocoumarin and is known to inhibit the growth of tumor cells. However, there is no available evidence that BGM has an inhibitory effect on cancer metastasis, specifically on the epithelial-to-mesenchymal transition (EMT) process in
the malignant cells. Here we aimed to evaluate the antimetastatic potential of BGM in human
lung adenocarcinoma cells. Our results demonstrate that BGM can block EMT, and observed
inhibition was accompanied by downregulation of fibronectin, vimentin, N-cadherin, twist and
snail expression, and upregulation of occludin and E-cadherin. Interestingly, transforming growth factor- (TGF-)-induced upregulation of fibronectin, vimentin, N-cadherin, twist and snail,
and downregulation of occludin and E-cadherin, were abrogated by BGM treatment. Moreover, the treatment of BGM repressed TGF--induced cell invasive potential. BGM treatment also inhibited multiple oncogenic cascades such as PI3K/Akt/mTOR. Overall, the results demonstrate the potential antimetastatic activity of BGM against lung cancer cells.
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