Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy

Title
Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy
Authors
구본철김영관홍유림강성훈이승현류성우민달희장홍제
Keywords
환원그래핀; 항암치료; 광발열; 생체고분자
Issue Date
2018-09
Publisher
Nanotechnology
Citation
VOL 29, NO 475604-11
Abstract
A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu– RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu– GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities.
URI
https://pubs.kist.re.kr/handle/201004/68289
ISSN
0957-4484
Appears in Collections:
KIST Publication > Article
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