Implication of multivalent aptamers in DNA and DNA-RNA hybrid structures for efficient drug delivery in vitro and in vivo

Title
Implication of multivalent aptamers in DNA and DNA-RNA hybrid structures for efficient drug delivery in vitro and in vivo
Authors
김선화곽기정강윤영송지현정희선Gyeonghui Yua안정훈목혜정
Issue Date
2018-04
Publisher
Journal of industrial and engineering chemistry
Citation
VOL 60-258
Abstract
To examine proper multivalency and type of aptamers in linear nucleic acid-based structures for efficient intracellular uptakes, we designed linear DNA structures with single and dual aptamers targeting guanosine-rich oligonucleotide 100 (AS1411) and mucin 1 (MUC-1). Multivalent linear DNA structures containing dual types of aptamers showed significantly superior cellular internalization. In addition, multivalent aptamer-immobilized DNA-RNA hybrid structures showed excellent tumor accumulation in vivo without liver toxicity and very low nonspecific cytokine induction. Thus, these multivalent nucleic acid based structures with dual types of aptamers can be specifically applied as carriers of therapeutic nucleic acids without inducing noticeable systemic toxicity.
URI
https://pubs.kist.re.kr/handle/201004/68683
ISSN
1226-086X
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE