Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection
- Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection
- 구종민; 샤자드 파이잘; Shabi Abbas Zaidi
- graphene; electrochemical sensor; sulfur doping
- Issue Date
- Sensors and actuators. B, Chemical
- VOL 241-724
- Herein, we demonstrate a sulfur-doped reduced graphene oxide (SrGO) product fabricated using an eco-friendly biomass precursor “lenthionine” through a high temperature doping process. The product is used for making a highly sensitive electrochemical sensor for detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) molecule, which is an important biomarker for oxidative stress, cardiovascular diseases, and cancers. The sulfur-doping amount was regulated and a maximum sulfur content of 2.28 atom% was achieved through controlling the precursor amount. Homogenous presence of large number of sulfur atoms in SrGO in the form of thiophenic (single bondCsingle bondSsingle bondCsingle bond) bond produced robust sensitivity (∼1 nM), very wide detection window (20– 0.002 μM), good selectivity, high stability and reproducibility, and excellent recoveries for the detection of 8-OHdG biomarker in optimized experimental conditions. The excellent electrochemical sensitivity of SrGO sensor is attributed to the strong electron-donating ability of sulfur that facilitates the electron transfer to the biomolecules in the electrochemical reactions. Thus, the proposed method endorses an excellent platform for the electrochemical detection of 8-OHdG with great ease and reliability.
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