Recent Developments in Metal-Catalyzed Bio-orthogonal Reactions for Biomolecule Tagging
- Recent Developments in Metal-Catalyzed Bio-orthogonal Reactions for Biomolecule Tagging
- 이준석; 디라제 무라레; 장세영; Anne Doyoung Kim
- biocatalysis; click chemistry
- Issue Date
- Chembiochem : a European journal of chemical biology
- VOL 20, NO 12-1507
- With the rapid advances in single-molecule and live-cell imaging studies to investigate biological problems, the role of chemical probes to monitor reactions in a live cell has considerably
increased. However, selective labeling of a target protein or a specific residue is highly challenging due to the high complexity of the biological system. In particular, biological macromolecules (such as proteins, DNA, or RNA) share many functional groups that potentially cross-react with exogenous chemical probes. Thus, there are high demands for perfect biocompatible
reactions utilizing biologically unavailable chemistry. Metal-catalyzed reactions have been extensively investigated as synthetic methodology studies, including initial attempts in applying the chemistry in aqueous solutions in vitro or even in biological conditions. Herein, the latest developments and progress in metal-catalyzed bio-orthogonal reactions for biomolecule labeling are summarized.
- Appears in Collections:
- KIST Publication > ETC
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.