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dc.contributor.author박진수-
dc.contributor.author이영기-
dc.contributor.authorManoj Koirala-
dc.contributor.authorMin Seon Kim-
dc.contributor.authorYou Chul Chung-
dc.contributor.authorSeung-Young Kim-
dc.date.accessioned2021-06-09T04:22:43Z-
dc.date.available2021-06-09T04:22:43Z-
dc.date.issued2019-05-
dc.identifier.citationVOL 14, NO 5-5-
dc.identifier.issn1934-578X-
dc.identifier.other53224-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/69859-
dc.description.abstractIn this study, a whole-cell biotransformation by Bacillus amyloliquefaciens Korean Collection for Type Culture 13588 was carried out to acquire naringenin derivatives. High-performance liquid chromatography analysis of the reaction metabolites showed the presence of 3 different products. The structure of the metabolites was confirmed through high-resolution quadrupole-time-of-flight electrospray-ionization mass spectrometry and nuclear magnetic resonance analysis. The result revealed that B. amyloliquefaciens catalyzes naringenin into 3 derivatives, naringenin 7-O-phosphate, naringenin 7-O-glucoside (prunin), and 6''-O-succinylprunin. To our knowledge, this is the first report of the production of 3 different derivatives when naringenin was used as a substrate. Furthermore, our study also revealed that the product naringenin 7-O-phosphate has approximately 45-fold higher water solubility than that of naringenin. Our finding suggests that biotransformation might solve the low bioavailability of flavonoids.-
dc.publisherNatural product communications-
dc.subjectbiotransformation-
dc.subjectBacillus amyloliquefaciens-
dc.subjectnaringenin-
dc.titleBiotransformation of Naringenin by Bacillus amyloliquefaciens Into Three Naringenin Derivatives-
dc.typeArticle-
dc.relation.page15-
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