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dc.contributor.author양현옥-
dc.contributor.author조동-
dc.contributor.author장리준-
dc.contributor.author곡명요-
dc.contributor.author전효진-
dc.contributor.author조용백-
dc.date.accessioned2021-06-09T04:22:53Z-
dc.date.available2021-06-09T04:22:53Z-
dc.date.issued2019-09-
dc.identifier.citationVOL 67, NO 35-9804-
dc.identifier.issn0021-8561-
dc.identifier.other53382-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/69999-
dc.description.abstractOveractivated microglia and persistent neuroinflammation hold an important role in the pathophysiology of neurodegenerative diseases. The extract of Lycoris chejuensis (CJ) and its active compound, 7-deoxy-trans-dihydronarciclasine (named E144), attenuated expressions of pro-inflammatory factors, including nitric oxide, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNF-α), and interleukin 6, secreted by lipopolysaccharide-activated BV-2 microglial cells, as measured by an enzyme-linked immunosorbent assay or western blotting. In contrast, CJ extract and E144 promoted the secretion of the anti-inflammatory cytokine, interleukin 10. Moreover, we found that E144 attenuated the expression of TNF-α and COX-2 in the cerebral cortex of lipopolysaccharide-treated mice and/or T2576 transgenic mice as well as reduced the reactive immune cells visualized by ionized calcium-binding adaptor molecule 1. Our results suggest the possibility of E144 to serve as a potential anti-neuroinflammatory agent by preventing excess production of pro-inflammatory factors.-
dc.publisherJournal of agricultural and food chemistry-
dc.title7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models-
dc.typeArticle-
dc.relation.page97969804-
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