A new-infrared probe targeting mitochondria via regulation of molecular hydrophobicity
- A new-infrared probe targeting mitochondria via regulation of molecular hydrophobicity
- 이상희; 추연정; 성준; 노준기; 전경; 민준식; 김종현; 김욱; 김은하
- Issue Date
- Bioconjugate chemistry
- VOL 30-217
- Herein, we developed a near-infrared (NIR) fluorescent probe for mitochondrial staining based on the NIR fluorochrome, silicon-rhodamine. The hydrophobicity of the fluorescent core was systematically modified by conjugation with 10 different commercial amines. The resulting fluorescent compounds exhibited similar photophysical properties but diverse hydrophobicity. We identified the optimal level of hydrophobicity associated with high mitochondrial targeting efficiency. In particular, the SiR-Mito 8 probe provided excellent mitochondrial staining and successfully differentiated the live Hep3B cancer cells from normal L02 cells in vitro.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.